The Relative Susceptibility to Infection and the Response to Immunization of Laboratory Animals in India and Abroad

The Drugs Rules, 1945, framed under the Drugs Act, 1940, are more or less an exact replica of the Statutory Rules and Orders made under the Therapeutic Substances Act of Great Britain. The question of the differences in susceptibility and reactivity of laboratory animals in India and England has not been taken into consideration. Taylor and Ahuja (1935) reported that ' White mice bred in Kasauli from imported English stock have been found to show a susceptibility to the toxic action of Novarsenobenzene different from that of the parent herd from which they* were derived The mice in England could tolerate a 43 per cent bigger dose than their offspring bred and reared in Kasauli. It is therefore essential to compare the response to injection of infective agents and antigens of laboratory animals in India and England before formulating any standards. The present work